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m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

25 Jun 2019

Abstract excerpt

Abstract Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade immunotherapy. FTO level is increased in human melanoma and enhances melanoma tumorigenesis in mice. FTO is induced by metabolic starvation stress through the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 31239444
DOI: 10.1038/s41467-019-10669-0

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