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Inhibition of UBA6 by inosine augments tumour immunogenicity and responses

15 Sept 2022

Abstract excerpt

Anti-cancer immunity and response to immune therapy is influenced by the metabolic states of the tumours. Immune checkpoint blockade therapy (ICB) is known to involve metabolic adaptation, however, the mechanism is not fully known. Here we show, by metabolic profiling of plasma samples from melanoma-bearing mice undergoing anti-PD1 and anti-CTLA4 combination therapy, that higher levels of purine metabolites,...

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PMID: 36109526
DOI: 10.1038/s41467-022-33116-z

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