Article
ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment.
Cell reports - 7 Mar 2017
Chen Chi-Fen, Ruiz-Vega Rolando, Vasudeva Priya, Espitia Francisco, Krasieva Tatiana B, de Feraudy Sebastien, Tromberg Bruce J, Huang Sharon, Garner Chad P, Wu Jie, Hoon Dave S, Ganesan Anand K
Abstract excerpt
Melanomas accumulate a high burden of mutations that could potentially generate neoantigens, yet somehow suppress the immune response to facilitate continued growth. In this study, we identify a subset of human melanomas that have loss-of-function mutations in ATR, a kinase that recognizes and repairs UV-induced DNA damage and is required for cellular proliferation. ATR mutant tumors exhibit both the accumulation...
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