Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic association of cholesterol metabolism with the risk of depression and schizophrenia.

Acta neuropsychiatrica - 1 Aug 2024

Chen Zheng, Sui Guanghong, Yang Caixia, Lv Zongshun, Wang Feng

Abstract excerpt

OBJECTIVE: Some observational studies have unexpectedly reported the association of cholesterol metabolism with mental and psychological disorders, but a firm conclusion has not been drawn. The aim of this study was to further investigate the effects of peripheral cholesterol traits and cholesterol-lowering therapy on depression and schizophrenia using a Mendelian randomisation approach. METHODS: Instrumental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hydroxymethylglutaryl CoA Reductases
Share to Cholesterol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, HDL

Share to Cholesterol, LDL

Share to Depression

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Mendelian Randomization Analysis

Share to Schizophrenia

Source

Identifiers

PMID: 39327862
DOI: 10.1017/neu.2024.26

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic association of cholesterol metabolism with the risk of depression and schizophrenia.PMID 39327862Read ↗

Risk of Neuropsychiatric Adverse Effects of Lipid-Lowering Drugs: A Mendelian Randomization Study.Semantic proximity Read ↗

Exploring repositioning opportunities and side-effects of statins: a Mendelian randomization study of HMG-CoA reductase inhibition with 55 complex traitsSemantic proximity Read ↗

Causal effects of lipid-lowering drug targets on psychiatric disorders: A drug-target Mendelian randomization study.Semantic proximity Read ↗

Investigating the potential anti-depressive mechanisms of statins: a transcriptomic and Mendelian randomization analysisSemantic proximity Read ↗

Gene-drug interactions identify genomic loci that enhance statin effectiveness in lowering LDL cholesterolSemantic proximity Read ↗

A Mendelian Randomization Approach Using 3-HMG-Coenzyme-A Reductase Gene Variation to Evaluate the Association of Statin-Induced Low-Density Lipoprotein Cholesterol Lowering With Noncardiovascular Disease Phenotypes.Semantic proximity Read ↗

Causal relationships between blood lipids and depression phenotypes: a Mendelian randomisation analysis.Semantic proximity Read ↗

Statins and antidepressants induce similar <i>in vitro</i> gene expression responsesSemantic proximity Read ↗

Genetic proxies for antihypertensive drugs and mental disorders: Mendelian randomization study in European and East Asian populationsSemantic proximity Read ↗

Gene-statin interaction study identifies 9 loci that moderate statin effectiveness in blood lipidsSemantic proximity Read ↗

Human genetics suggests differing causal pathways from<i>HMGCR</i>inhibition to coronary artery disease and type 2 diabetesSemantic proximity Read ↗

Differential associations of statin treatment and polymorphism in genes coding for HMGCR and PCSK9 to risk for insomnia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.