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Article

Causal effects of lipid-lowering drug targets on psychiatric disorders: A drug-target Mendelian randomization study.

The Journal of international medical research - 1 Jan 2026

Wang Yan, Liu Xin, Huang Shuo

Abstract excerpt

ObjectivesThe pleiotropic effects of lipid-lowering therapies on mental health remain incompletely understood. This study aimed to investigate the causal impact of genetically proxied inhibition of three major lipid-lowering drug targets, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), Niemann-Pick C1-like protein 1 (NPC1L1), and proprotein convertase subtilisin/kexin type 9 (PCSK9), on a spectrum of...

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Source

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Identifiers

PMID: 41618764
DOI: 10.1177/03000605261416738
PMCID: PMC12861347

Genes

HMGCR
NPC1L1
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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