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Article

Differential associations of statin treatment and polymorphism in genes coding for HMGCR and PCSK9 to risk for insomnia.

Frontiers in bioscience (Landmark edition) - 30 Dec 2021

Alsehli Ahmed M, Rukh Gull, Clemensson Laura E, Ciuculete Diana-Maria, Tan Xiao, Al-Sabri Mohamed H, Williams Michael J, Benedict Christian, Schiöth Helgi B

Abstract excerpt

IMPORTANCE: Statins have been linked to an increased risk for insomnia, but the literature is controversial. Moreover, it is unknown, if the potential effects are directly related to the inhibition of the statin target HMGCR, the subsequently lowered cholesterol levels, or other off-target effects of statins. AIMS: To investigate the association of statin treatment and genetic proxies of cholesterol lowering...

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Share to Cholesterol, LDL
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Hydroxymethylglutaryl CoA Reductases

Share to Polymorphism, Single Nucleotide

Share to Proprotein Convertase 9

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Identifiers

PMID: 34994160
DOI: 10.52586/5039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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