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Article

Impaired arterial dilation and increased NOX2 generated oxidative stress in subjects with ataxia-telangiectasia mutated (ATM) kinase.

Redox biology - 1 Nov 2024

Loffredo Lorenzo, Soresina Annarosa, Cinicola Bianca Laura, Capponi Martina, Salvatori Francesca, Bartimoccia Simona, Picchio Vittorio, Forte Maurizio, Caputi Caterina, Poscia Roberto, Leuzzi Vincenzo, Spalice Alberto, Pignatelli Pasquale, Badolato Raffaele, Duse Marzia, Violi Francesco, Carnevale Roberto, Zicari Anna Maria

Abstract excerpt

BACKGROUND: Subjects with mutations in the Ataxia-Telangiectasia mutated (ATM) gene encoding for ATM kinase have a greater predisposition to develop atherosclerosis, but the mechanism behind this phenomenon is not yet understood. NADPH oxidase type 2 may play a role in this process, leading to endothelial dysfunction and an increased susceptibility to thrombosis. The purpose of this study was to assess the redox...

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Identifiers

PMID: 39326070
DOI: 10.1016/j.redox.2024.103347
PMCID: PMC11466602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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