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Article

Reduction of double-strand DNA break repair exacerbates vascular aging

2 Oct 2023

Abstract excerpt

Advanced age is the greatest risk factor for cardiovascular disease (CVD), the leading cause of death. Arterial function is impaired in advanced age which contributes to the development of CVD. One underexplored hypothesis is that DNA damage within arteries leads to this dysfunction, yet evidence demonstrating the incidence and physiological consequences of DNA damage in arteries, and in particular, in the...

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PMID: 37787989
DOI: 10.18632/aging.205066

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