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Bradykinin and oxidative stress in patients with hereditary angioedema due to C1 inhibitor deficiency.

Polish archives of internal medicine - 27 Feb 2020

Obtułowicz Krystyna, Góralska Joanna, Bogdali Anna, Dyga Wojciech, Obtułowicz Aleksander, Myszkowska Dorota, Ziemianin Monika, Gruca Anna, Solnica Bogdan, Czarnobilska Ewa

Abstract excerpt

INTRODUCTION: Hereditary angioedema (HAE) is a rare autosomal dominant disease caused by genetic dysfunction of C1 inhibitor (C1-INH) due to mutations in the SERPING1 gene. The disorder is mediated mainly by bradykinin. The clinical course of the disease is varied and not related to genetic changes. OBJECTIVES: We aimed to evaluate redox homeostasis of peripheral blood mononuclear cells (PBMCs) in patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31933486
DOI: 10.20452/pamw.15138

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