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Fluctuations and the limit of predictability in protein evolution.

Reports on progress in physics. Physical Society (Great Britain) - 9 Jul 2025

Rossi Saverio, Di Bari Leonardo, Weigt Martin, Zamponi Francesco

Abstract excerpt

Protein evolution involves mutations occurring across a wide range of time scales. In analogy with disordered systems in statistical physics, this dynamical heterogeneity suggests strong correlations between mutations happening at distinct sites and times. To quantify these correlations, we examine the role of various fluctuation sources in protein evolution, simulated using a data-driven energy landscape as a...

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PMID: 40592352
DOI: 10.1088/1361-6633/adea92

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