Article
Molecular ensembles make evolution unpredictable.
Proceedings of the National Academy of Sciences of the United States of America - 7 Nov 2017
Sailer Zachary R, Harms Michael J
Abstract excerpt
Evolutionary prediction is of deep practical and philosophical importance. Here we show, using a simple computational protein model, that protein evolution remains unpredictable, even if one knows the effects of all mutations in an ancestral protein background. We performed a virtual deep mutational scan-revealing the individual and pairwise epistatic effects of every mutation to our model protein-and then used...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.