Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system.

doi:10.1016/0092-8674(92)90286-l

Article

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system.

Cell - 29 May 1992

Lee K F, Li E, Huber L J, Landis S C, Sharpe A H, Chao M V, Jaenisch R

Abstract excerpt

We have generated mice carrying a mutation of the gene encoding the low affinity NGF receptor p75NGFR by targeted mutation in embryonic stem cells. Mice homozygous for the mutation were viable and fertile. Immunohistochemical analyses of the footpad skin of mutant mice revealed markedly decreased...

Topics

Animals
Blotting, Western
Cell Line
Female
Iris
Male
Mice
Mice, Inbred BALB C
Mutation
Nerve Growth Factors
Neurons, Afferent
Nucleotide Mapping
Receptors, Cell Surface
Receptors, Nerve Growth Factor
Salivary Glands
Skin

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system.

Abstract excerpt

Topics

Discuss the evidence