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Interferon Stimulated Gene Expression Is a Biomarker for Primary Mitochondrial Disease

25 Sept 2024

Abstract excerpt

OBJECTIVE: Mitochondria are implicated in regulation of the innate immune response. We hypothesized that abnormalities in interferon signaling may contribute to pathophysiology in patients with primary mitochondrial disease (PMD). METHODS: Expression of interferon stimulated genes (ISGs) was measured by real-time polymerase chain reaction (PCR) in whole blood samples from a cohort of patients with PMD. RESULTS:...

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PMID: 39320038
DOI: 10.1002/ana.27081

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