Article
Type I Interferon Signature is Associated With Lung Disease, Drug-Associated Immune Reactions, and Genetic Variation in Interferon-Linked Pathways in Still Disease.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Aug 2026
Marques Mariana Correia, Deng Zuoming, Chowdhury Navid, Schmitz Elizabeth, Platukus Alana, Rosenbaum Emily D, Lu Shajia, Brooks Stephen, Gadina Massimo, Kim Hanna, Lake Carol, Bergeron Ly-Lan, Millwood Michelle, Ombrello Michael J
Abstract excerpt
OBJECTIVE: To evaluate the relationship across type I interferon (IFN-I)-stimulated gene (ISG) expression, Still disease, and the development of lung disease (LD) and drug-associated immune reactions (DAIR) to interleukin-1 (IL-1) and/or IL-6 inhibitors. METHODS: Whole blood ISG expression was quantified by NanoString array. ISG-28 scores were calculated in consecutive patients with Still or Still-like disease....
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