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IFNγ modestly contributes to disease progression in the Ndufs4 (-/-) model of Leigh syndrome while IP10 is dispensable

2023-07-10

Abstract excerpt

Leigh syndrome (LS) is the most common pediatric presentation of genetic mitochondrial disease. LS is a multi-system disease characterized by severe neurologic and metabolic abnormalities. The defining feature of the disease is the presence of symmetric, bilateral, progressive necrotizing lesions in the brain stem, cerebellum, and basal ganglia. The pathogenic mechanisms underlying disease initiation and progressi...

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Literature Corpus work: c5ada189-a7ee-5d13-a7eb-e56f162c6027
DOI: 10.1101/2023.07.09.548281

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IFNγ modestly contributes to disease progression in the Ndufs4 (-/-) model of Leigh syndrome while IP10 is dispensableDOI 10.1101/2023.07.09.548281Read

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IFNγ modestly contributes to disease progression in the <i>Ndufs4</i> (-/-) model of Leigh syndrome while IP10 is dispensable

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