Article
Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution.
Nature genetics - 1 Oct 2024
Schiffman Joshua S, D'Avino Andrew R, Prieto Tamara, Pang Yakun, Fan Yilin, Rajagopalan Srinivas, Potenski Catherine, Hara Toshiro, Suvà Mario L, Gawad Charles, Landau Dan A
Abstract excerpt
Single-cell sequencing has characterized cell state heterogeneity across diverse healthy and malignant tissues. However, the plasticity or heritability of these cell states remains largely unknown. To address this, we introduce PATH (phylogenetic analysis of trait heritability), a framework to quantify cell state heritability versus plasticity and infer cell state transition and proliferation dynamics from...
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