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Single-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma

8 Apr 2024

Abstract excerpt

Hepatoblastomas (HB) display heterogeneous cellular phenotypes that influence the clinical outcome, but the underlying mechanisms are poorly understood. Here, we use a single-cell multiomic strategy to unravel the molecular determinants of this plasticity. We identify a continuum of HB cell states between hepatocytic (scH), liver progenitor (scLP) and mesenchymal (scM) differentiation poles, with an intermediate...

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PMID: 38589411
DOI: 10.1038/s41467-024-47280-x

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