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Article

The Origins of Phenotypic Heterogeneity in Cancer.

Cancer research - 1 Jan 2022

Lenz Guido, Onzi Giovana R, Lenz Luana S, Buss Julieti H, Dos Santos Jephesson A, Begnini Karine R

Abstract excerpt

Heterogeneity is a pervasive feature of cancer, and understanding the sources and regulatory mechanisms underlying heterogeneity could provide key insights to help improve the diagnosis and treatment of cancer. In this review, we discuss the origin of heterogeneity in the phenotype of individual cancer cells. Genotype-phenotype (G-P) maps are widely used in evolutionary biology to represent the complex...

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PMID: 34785576
DOI: 10.1158/0008-5472.CAN-21-1940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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