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Article

Age-induced changes in skeletal muscle mitochondrial DNA synthesis, quantity, and quality in genetically unique rats.

GeroScience - 1 Feb 2025

Musci Robert V, Fuqua Jordan D, Peelor Frederick F, Nguyen Hoang Van Michelle, Richardson Arlan, Choi Solbie, Miller Benjamin F, Wanagat Jonathan

Abstract excerpt

Mitochondrial genomic integrity is a key element of physiological processes and health. Changes in the half-life of the mitochondrial genome are implicated in the generation and accumulation of age-induced mitochondrial DNA (mtDNA) mutations, which are implicated in skeletal muscle aging and sarcopenia. There are conflicting data on the half-life of mtDNA, and there is limited information on how aging affects...

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Identifiers

PMID: 39312152
DOI: 10.1007/s11357-024-01344-4
PMCID: PMC11872842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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