Article
Mitochondrial DNA deletion mutations and sarcopenia.
Annals of the New York Academy of Sciences - 1 Apr 2002
Aiken Judd, Bua Entela, Cao Zhengjin, Lopez Marisol, Wanagat Jon, McKenzie Debbie, McKiernan Susan
Abstract excerpt
This manuscript summarizes our studies on mitochondrial DNA and enzymatic abnormalities that accumulate, with age, in skeletal muscle. Specific quadricep muscles, rectus femoris in the rat and vastus lateralis in the rhesus monkey, were used in these studies. These muscles exhibit considerable sarcopenia, the loss of muscle mass with age. The focal accumulation of mtDNA deletion mutations and enzymatic...
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