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Mitochondria, Cellular Stress Resistance, Somatic Cell Depletion and Lifespan

1 Feb 2009

Abstract excerpt

The causes of aging and determinants of maximum lifespan in animal species are multifaceted and complex. However, a wealth of experimental data suggests that mitochondria are involved both in the aging process and in regulating lifespan. Here we outline a somatic cell depletion (SCD) model to account for correlations between: (1) mitochondrial reactive oxygen species and lifespan; (2) mitochondrial antioxidant...

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PMID: 20021396
DOI: 10.2174/1874609810902010012

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