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Article

Mitochondrial function as a determinant of life span

9 Sept 2009

Abstract excerpt

Average human life expectancy has progressively increased over many decades largely due to improvements in nutrition, vaccination, antimicrobial agents, and effective treatment/prevention of cardiovascular disease, cancer, etc. Maximal life span, in contrast, has changed very little. Caloric restriction (CR) increases maximal life span in many species, in concert with improvements in mitochondrial function. These...

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PMID: 19756719
DOI: 10.1007/s00424-009-0724-5

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