Article

Remdesivir does not affect mitochondrial DNA copy number or deletion mutation frequency in aged male rats

2022-07-10

Abstract excerpt

Remdesivir is a leading therapy in patients with moderate to severe coronavirus 2 (SARS-CoV-2) infection; the majority of whom are older individuals. Remdesivir is a nucleoside analog that incorporates into nascent viral RNA, inhibiting RNA-directed RNA polymerases, including that of SARS-CoV-2. Less is known about remdesivir’s effects on mitochondria, particularly in older adults where mitochondria are known to b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c15cf6da-211b-5b3c-a049-0326ffa7bf82
DOI: 10.1101/2022.07.10.499455

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 10 closest

Remdesivir does not affect mitochondrial DNA copy number or deletion mutation frequency in aged male ratsDOI 10.1101/2022.07.10.499455Read

Age-induced changes in skeletal muscle mitochondrial DNA synthesis, quantity, and quality in genetically unique rats.Semantic proximity Read

Low levels of mtDNA deletion mutations in ETS normal fibers from aged rats.Semantic proximity Read

Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber loss.Semantic proximity Read

Mitochondrial DNA sequences are present inside nuclear DNA in rat tissues and increase with age.Semantic proximity Read

Mitochondrial DNA rearrangements, including partial duplications, occur in young and old rat tissues.Semantic proximity Read

Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection.Semantic proximity Read

Age-associated changes in function, structure and mitochondrial genetic and enzymatic abnormalities in the Fischer 344 x Brown Norway F(1) hybrid rat heart.Semantic proximity Read

Detection of a specific mitochondrial DNA deletion in tissues of older humans.Semantic proximity Read

Quantification of mitochondrial DNA deletion, depletion, and overreplication: application to diagnosis.Semantic proximity Read