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Article

Person-level contributions of bipolar polygenic risk score to the prediction of new-onset bipolar disorder in at-risk offspring.

Journal of affective disorders - 1 Jan 2025

Hafeman Danella M, Uher Rudolf, Merranko John, Zwicker Alyson, Goldstein Benjamin, Goldstein Tina R, Axelson David, Monk Kelly, Sakolsky Dara, Iyengar Satish, Diler Rasim, Nimgaonkar Vishwajit, Birmaher Boris

Abstract excerpt

BACKGROUND: Previous work indicates that polygenic risk scores (PRS) for bipolar disorder (BD) are elevated in adults and youth with BD, but whether BD-PRS can inform person-level diagnostic prediction is unknown. Here, we test whether BD-PRS improves performance of a previously published risk calculator (RC) for BD. METHODS: 156 parents with BD-I/II and their offspring ages 6-18 were recruited and evaluated with...

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PMID: 39299598
DOI: 10.1016/j.jad.2024.09.107

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