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Article

Role of Polygenic Risk Score in the Familial Transmission of Bipolar Disorder in Youth.

JAMA psychiatry - 1 Feb 2022

Birmaher Boris, Hafeman Danella, Merranko John, Zwicker Alyson, Goldstein Benjamin, Goldstein Tina, Axelson David, Monk Kelly, Hickey Mary Beth, Sakolsky Dara, Iyengar Satish, Diler Rasim, Nimgaonkar Vishwajit, Uher Rudolf

Abstract excerpt

Importance: Establishing genetic contributions to the transmission of bipolar disorder (BD) from parents to offspring may inform the risk of developing this disorder and further serve to validate BD in youth. Objective: To evaluate the specific association of BD polygenic risk scores (PRSs) on the familial transmission and validity of pediatric BD. Design, Setting, and Participants: This community-based...

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Identifiers

PMID: 34935868
DOI: 10.1001/jamapsychiatry.2021.3700
PMCID: PMC8696688

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