Psychiatric Polygenic Risk Scores and Week-by-Week Symptomatic Status in Youth with Bipolar Disorder: An Exploratory Study.

doi:10.1089/cap.2024.0130

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Article

Psychiatric Polygenic Risk Scores and Week-by-Week Symptomatic Status in Youth with Bipolar Disorder: An Exploratory Study.

Journal of child and adolescent psychopharmacology - 1 Jun 2025

Jiang Xinyue, Zai Clement C, Merranko John, Young L Trevor, Birmaher Boris, Goldstein Benjamin I

Abstract excerpt

Introduction: Prior studies have demonstrated that, in both adults and youth, bipolar disorder (BD) is a polygenic illness. However, no studies have examined polygenic risk scores (PRSs) in relation to the longitudinal course of mood symptoms in youth with BD. Methods: This study included 246 youth of European ancestry with BD (7-20 years old at intake) from the Course and Outcome of Bipolar Youth study and...

Read the complete abstract on PubMed

Topics

Humans
Bipolar Disorder
Adolescent
Male
Female
Young Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Multifactorial Inheritance

Child

Attention Deficit Disorder with Hyperactivity

Major Depressive Disorder

Prospective Studies

Longitudinal Studies

Genome-Wide Association Study

Schizophrenia

Genetic Predisposition to Disease

Risk Factors

Severity of Illness Index

Genetic Risk Score

Source

Open in PubMed

Identifiers

PMID: 40059772
DOI: 10.1089/cap.2024.0130

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