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Article

A high cholesterol diet aggravates experimental colitis through SREBP2-modulated endocytosis and degradation of occludin and Zo-1 proteins.

The FEBS journal - 1 Mar 2025

Yang Qin, Li Yongjia, Wang Xingxing, Ding Qiuying, Tao Yi, Li Pan, Lian Xuemei, Chen Yaxi, Zhao Lei

Abstract excerpt

Disrupted cholesterol homeostasis plays a critical role in the development of multiple diseases, such as cardiovascular disease and cancer. However, the role of cholesterol in inflammatory bowel disease (IBD) remains unclear. In the present study, we investigated whether and how high levels of cholesterol in the diet affect experimental colitis in mice. A normal diet supplemented with 1.25% cholesterol (high...

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Identifiers

PMID: 39279038
DOI: 10.1111/febs.17269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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