Article

ApoC-III overexpression and LDLr-/- protect mice from DSS-colitis: identifying a new role for lipoprotein metabolism in Tregs

2019-11-05

Abstract excerpt

<h4>Objective</h4> Cellular metabolism is a key regulator of CD4 + Foxp3 + regulatory T cell (Treg) homeostasis, but the foundational studies in this area use free fatty acid treatment as a proxy for plasma triglycerides. In vivo, plasma triglyceride is the main source of fatty acids for cells, not free fatty acids. <h4>Design/Results</h4> Using apolipoprotein C-III transgenic and LDLr -/- mice, we report th...

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Literature Corpus work: 7c2ae3e6-eec9-5d99-a1e6-bb0c235a2834
DOI: 10.1101/823690

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