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Article

High fat diet accelerates pathogenesis of murine Crohn's disease-like ileitis independently of obesity.

PloS one - 1 Jan 2013

Gruber Lisa, Kisling Sigrid, Lichti Pia, Martin François-Pierre, May Stephanie, Klingenspor Martin, Lichtenegger Martina, Rychlik Michael, Haller Dirk

Abstract excerpt

BACKGROUND: Obesity has been associated with a more severe disease course in inflammatory bowel disease (IBD) and epidemiological data identified dietary fats but not obesity as risk factors for the development of IBD. Crohn's disease is one of the two major IBD phenotypes and mostly affects the terminal ileum. Despite recent observations that high fat diets (HFD) impair intestinal barrier functions and drive...

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Identifiers

PMID: 23977107
DOI: 10.1371/journal.pone.0071661
PMCID: PMC3745443

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TNF

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