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CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice

13 Apr 2011

Abstract excerpt

Expression of the transmembrane glycoprotein CD98 (encoded by SLC3A2) is increased in intestinal inflammatory conditions, such as inflammatory bowel disease (IBD), and in various carcinomas, yet its pathogenetic role remains unknown. By generating gain- and loss-of-function mouse models with genetically manipulated CD98 expression specifically in intestinal epithelial cells (IECs), we explored the role of CD98 in...

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PMID: 21490400
DOI: 10.1172/jci44631

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