Article

Autophagy Increases Occludin Levels to Enhance Intestinal Paracellular Tight Junction Barrier

2022-04-11

Abstract excerpt

<h4>Background and Aim</h4> Functional loss of paracellular tight junction (TJ) barrier of the gut epithelium and mutations in autophagy genes are factors potentiating inflammatory bowel disease ( IBD ). Previously we showed the role of autophagy in enhancing the TJ barrier via claudin-2 degradation, however, its role in the regulation of the barrier-forming protein occludin remains unknown. Here, we investigate...

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Literature Corpus work: ed747b9a-f256-5d49-9c7f-7ea3ae106c06
DOI: 10.1101/2022.04.11.487876

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