Article

Autophagy prevents ER stress-induced Tight Junction barrier disruption via claudin-2 homeostasis

2026-07-20

Abstract excerpt

Defective intestinal epithelial tight junction (TJ) barrier function and endoplasmic reticulum (ER) stress are central pathological features of inflammatory bowel disease (IBD), yet the molecular mechanisms ER stress to TJ disruption remains poorly understood. Here, we investigated the role of autophagy in regulating intestinal TJ homeostasis during ER stress. ER stress was elevated in inflamed Crohn’s disease tis...

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Literature Corpus work: a21a374b-8f0a-5119-a6b6-7563a882f574
DOI: 10.64898/2026.07.15.738672

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