Article
Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes.
Science advances - 2 May 2025
Hiitola Emil, Korhonen Juuso, Kokkonen Heidi, Koskela Jukka, Kankainen Matti, Alakuijala Milla, Liu Aoxing, Lundgren Sofie, Häppölä Paavo, Almusa Henrikki, Ellonen Pekka, Savola Paula, Kelkka Tiina, Leirisalo-Repo Marjatta, Koivuniemi Riitta, Peltomaa Ritva, Pirilä Laura, Isomäki Pia, Kauppi Markku, Kaipiainen-Seppänen Oili, Starskaia Inna, Virtanen Anniina T, Lahesmaa Riitta, Silvennoinen Olli, Genovese Giulio, Ganna Andrea, Rantapää-Dahlqvist Solbritt, Mustjoki Satu, Myllymäki Mikko
Abstract excerpt
Clonal hematopoiesis (CH) becomes more prevalent with aging and may influence inflammatory diseases by altering immune function. While CH of indeterminate potential (CHIP) promotes inflammation in nonmalignant conditions, its relationship with rheumatoid arthritis (RA) remains unknown. We analyzed CHIP mutations in RA using two population-level cohorts and patients with newly diagnosed RA. CHIP was associated...
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