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Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes

30 Apr 2025

Abstract excerpt

Clonal hematopoiesis (CH) becomes more prevalent with aging and may influence inflammatory diseases by altering immune function. While CH of indeterminate potential (CHIP) promotes inflammation in nonmalignant conditions, its relationship with rheumatoid arthritis (RA) remains unknown. We analyzed CHIP mutations in RA using two population-level cohorts and patients with newly diagnosed RA. CHIP was associated...

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PMID: 40305610
DOI: 10.1126/sciadv.adt9846

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