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Article

Clonal hematopoiesis with DNMT3A mutation is associated with lower white matter hyperintensity volume.

CNS neuroscience & therapeutics - 1 May 2023

Lee Woo-Jin, Jung Keun-Hwa, Song Han, Lee Heesun, Park Hyo Eun, Koh Youngil, Choi Su-Yeon, Park Kyung-Il

Abstract excerpt

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) increases the risk of cerebrovascular events, while its association with cerebral white matter hyperintensity (WMH) is undemonstrated. We evaluated the effect of CHIP and its major driving mutations on cerebral WMH severity. METHODS: From an institutional cohort of a routine health check-up program with a DNA repository database, subjects who were...

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Identifiers

PMID: 36807865
DOI: 10.1111/cns.14114
PMCID: PMC10068463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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