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Article

A Study on the Binding Mechanism and the Impact of Key Residue Mutations between SND1 and MTDH Peptide through Molecular Dynamics Simulations.

The journal of physical chemistry. B - 26 Sept 2024

Liu Senchen, Hao Xiafei, Miao Dongqiang, Zhang Yanjun

Abstract excerpt

Metastasis of breast cancer is the main cause of death for patients with breast cancer. The interaction between metadherin (MTDH) and staphylococcal nuclease domain 1 (SND1) plays a pivotal role in promoting breast cancer development. However, the binding details between MTDH and SND1 remain unclear. In this study, we employed all-atom molecular dynamics simulations (MDs) and conducted binding energy calculations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39276108
DOI: 10.1021/acs.jpcb.4c02325

Genes

MTDH
SND1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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