Article
MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.
Cancer cell - 14 Jul 2014
Wan Liling, Lu Xin, Yuan Salina, Wei Yong, Guo Feng, Shen Minhong, Yuan Min, Chakrabarti Rumela, Hua Yuling, Smith Heath A, Blanco Mario Andres, Chekmareva Marina, Wu Hao, Bronson Roderick T, Haffty Bruce G, Xing Yongna, Kang Yibin
Abstract excerpt
The Metadherin gene (MTDH) is prevalently amplified in breast cancer and associated with poor prognosis; however, its functional contribution to tumorigenesis is poorly understood. Using mouse models representing different subtypes of breast cancer, we demonstrated that MTDH plays a critical role in mammary tumorigenesis by regulating oncogene-induced expansion and activities of tumor-initiating cells (TICs),...
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