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Article

Affinity enhancement of nanobody binding to EGFR: in silico site-directed mutagenesis and molecular dynamics simulation approaches.

Journal of biomolecular structure & dynamics - 1 Jun 2017

Farasat Alireza, Rahbarizadeh Fatemeh, Hosseinzadeh Ghader, Sajjadi Sharareh, Kamali Mehdi, Keihan Amir Homayoun

Abstract excerpt

Epidermal growth factor receptor (EGFR), a transmembrane glycoprotein, is overexpressed in many cancers such as head-neck, breast, prostate, and skin cancers for this reason it is a good target in cancer therapy and diagnosis. In nanobody-based cancer diagnosis and treatment, nanobodies with high affinity toward receptor (e.g. EGFR) results in effective treatment or diagnosis of cancer. In this regard, the main...

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Identifiers

PMID: 27691399
DOI: 10.1080/07391102.2016.1192065

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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