Article
Computational structural assessment of BReast CAncer type 1 susceptibility protein (BRCA1) and BRCA1-Associated Ring Domain protein 1 (BARD1) mutations on the protein-protein interface.
Advances in protein chemistry and structural biology - 1 Jan 2022
Thirumal Kumar D, Udhaya Kumar S, Jain Nikita, Sowmya Baviri, Balsekar Kamakshi, Siva R, Kamaraj Balu, Sidenna Mariem, George Priya Doss C, Zayed Hatem
Abstract excerpt
Breast cancer type 1 susceptibility protein (BRCA1) is closely related to the BRCA2 (breast cancer type 2 susceptibility protein) and BARD1 (BRCA1-associated RING domain-1) proteins. The homodimers were formed through their RING fingers; however they form more compact heterodimers preferentially, influencing BRCA1 residues 1-109 and BARD1 residues 26-119. We implemented an integrative computational pipeline to...
Topics
Join the communities discussing this publication.