Article

Deciphering GB1’s Single Mutational Landscape: Insights from MuMi Analysis

2024-06-03

Abstract excerpt

<h4>ABSTRACT</h4> Mutational changes that affect the binding of the C2 fragment of Streptococcal protein G (GB1) to the Fc domain of human IgG (IgG-Fc) have been extensively studied using deep mutational scanning (DMS), and the binding affinity of all single mutations has been measured experimentally in the literature. To investigate the underlying molecular basis, we perform in-silico mutational scanning for al...

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Literature Corpus work: 6b7ed5d6-0c47-533b-bdfd-46bc75613a4f
DOI: 10.1101/2024.06.01.596930

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