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Article

Structural effects of the L145Q, V157F, and R282W cancer-associated mutations in the p53 DNA-binding core domain.

Biochemistry - 14 Jun 2011

Calhoun Sara, Daggett Valerie

Abstract excerpt

The p53 tumor suppressor is a transcription factor involved in many important signaling pathways, such as apoptosis and cell-cycle arrest. In over half of human cancers, p53 function is compromised by a mutation in its gene. Mutations in the p53 DNA-binding core domain destabilize the structure and reduce DNA-binding activity. We performed molecular dynamics simulations at physiological temperature to study the...

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Identifiers

PMID: 21561095
DOI: 10.1021/bi200192j
PMCID: PMC3117291

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Structural effects of the L145Q, V157F, and R282W cancer-associated mutations in the p53 DNA-binding core domain.PMID 21561095Read ↗

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