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Article

Exploring binding modes of the selected inhibitors to SND1 by all-atom molecular dynamics simulations.

Journal of biomolecular structure & dynamics - 1 Jul 2024

Pang Peilin, Liu Senchen, Hao Xiafei, Tian Yuxin, Gong Shuyue, Miao Dongqiang, Zhang Yanjun

Abstract excerpt

Breast cancer is the leading cause of cancer-related deaths in women. Previous studies have indicated that disrupting the interaction between Metadherin (MTDH) and Staphylococcal nuclease domain containing 1 (SND1) can inhibit breast cancer development. Understanding the binding mode of small molecule inhibitors with SND1 is of great significance for designing drugs targeting the MTDH-SND1 complex. In this study,...

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PMID: 37345536
DOI: 10.1080/07391102.2023.2226737

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