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Article

Genetic polymorphism in untranslated regions of PRKCZ influences mRNA structure, stability and binding sites.

BMC cancer - 13 Sept 2024

Mustafa Aneela, Shabbir Maria, Badshah Yasmin, Khan Khushbukhat, Abid Fizzah, Trembley Janeen H, Afsar Tayyaba, Almajwal Ali, Razak Suhail

Abstract excerpt

BACKGROUND: Variations in untranslated regions (UTR) alter regulatory pathways impacting phenotype, disease onset, and course of disease. Protein kinase C Zeta (PRKCZ), a serine-threonine kinase, is implicated in cardiovascular, neurological and oncological disorders. Due to limited research on PRKCZ, this study aimed to investigate the impact of UTR genetic variants' on binding sites for transcription factors...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39272077
DOI: 10.1186/s12885-024-12900-8
PMCID: PMC11401371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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