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Article

Human non-synonymous single nucleotide polymorphisms can influence ubiquitin-mediated protein degradation.

Omics : a journal of integrative biology - 1 Jan 2007

Savas Sevtap, Shariff Mehjabeen, Taylor Ian W, Ozcelik Hilmi

Abstract excerpt

Ubiquitin-mediated proteolysis plays a critical role in the degradation of proteins important in the cellular processes, such as cell cycle/division, differentiation and development, DNA repair, transcriptional regulation, and signaling. It is carried out by a complex cascade of enzymes that contain a high degree of specificity to motifs found in many proteins with rapid turnover. For example, the PEST motifs are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17594238
DOI: 10.1089/omi.2007.4324

Genes

CCND3
NEIL2
PMS2
POLE4
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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