Article
Pre-B cells in kappa-transgenic mice.
Nature - 1 Jan 2000
Storb U, Denis K A, Brinster R L, Witte O N
Abstract excerpt
Recent experiments have shown that the microinjected kappa-chain gene of transgenic mice is expressed in a tissue-specific fashion only in B lymphocytes. The next step was to determine whether, within the B-lymphocyte lineage, the kappa-chain gene was expressed in a normal developmental fashion....
Topics
- Abelson murine leukemia virus
- Alleles
- Animals
- B-Lymphocytes
- Bone Marrow Cells
- Cell Line
- Cell Transformation, Viral
- DNA
- Gene Expression Regulation
- Genetic Engineering
- Hematopoietic Stem Cells
- Immunoglobulin Light Chains
- Immunoglobulin kappa-Chains
- Immunoglobulin mu-Chains
- Mice
- Phenotype
- RNA, Messenger
- Transcription, Genetic