Article
Pre-B cells in kappa-transgenic mice.
Nature - 1 Jan 2000
Storb U, Denis K A, Brinster R L, Witte O N
Abstract excerpt
Recent experiments have shown that the microinjected kappa-chain gene of transgenic mice is expressed in a tissue-specific fashion only in B lymphocytes. The next step was to determine whether, within the B-lymphocyte lineage, the kappa-chain gene was expressed in a normal developmental fashion. Normally, only mu heavy(H)-chain genes, and not kappa-chain genes, are expressed in pre-B cells. To obtain cloned cell...
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