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Article

A human immunoglobulin lambda locus is similarly well expressed in mice and humans.

The Journal of experimental medicine - 17 May 1999

Popov A V, Zou X, Xian J, Nicholson I C, Brüggemann M

Abstract excerpt

Transgenic mice carrying a 380-kb region of the human immunoglobulin (Ig) lambda light (L) chain locus in germline configuration were created. The introduced translocus on a yeast artificial chromosome (YAC) accommodates the most proximal Iglambda variable region (V) gene cluster, including 15 Vlambda genes that contribute to >60% of lambda L chains in humans, all Jlambda-Clambda segments, and the 3' enhancer....

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Source

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Identifiers

PMID: 10330440
DOI: 10.1084/jem.189.10.1611
PMCID: PMC2193639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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