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Article

Association of methylenetetrahydrofolate reductase gene C677T polymorphism with multiple sclerosis in Turkish patients.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Dec 2014

Cevik Betul, Yigit Serbulent, Karakus Nevin, Aksoy Durdane, Kurt Semiha, Ates Omer

Abstract excerpt

BACKGROUND AND AIM: Multiple sclerosis (MS) is a chronic neurodegenerative autoimmune disease of the central nervous system. Genetic risk factors are known to contribute to the etiology of MS. Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism has been associated with susceptibility to various autoimmune diseases. The aim of this study was to investigate a possible association between the MTHFR...

Topics

Adult
Case-Control Studies
Demography
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multiple Sclerosis

Polymorphism, Single Nucleotide

Turkey

Source

Identifiers

PMID: 25203152
DOI: 10.1097/JIM.0000000000000107

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25203152-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Association of methylenetetrahydrofolate reductase gene C677T polymorphism with multiple sclerosis in Turkish patients.PMID 25203152Read ↗

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