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Article

Genetic variants of homocysteine metabolism and multiple sclerosis: a case-control study.

Neuroscience letters - 6 Mar 2014

Ineichen Benjamin V, Keskitalo Salla, Farkas Melinda, Bain Nadja, Kallweit Ulf, Weller Michael, Klotz Luisa, Linnebank Michael

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is necessary for the synthesis of methionine and S-adenosylmethionine, which is necessary for CNS (re-)myelination. The MTHFR variant c.1298A>C was associated with the development of relapsing remitting multiple sclerosis (RRMS) in a German population. This study aimed at analyzing whether further genetic variants of methionine metabolism are associated with the...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Cystathionine beta-Synthase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

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Source

Identifiers

PMID: 24412677
DOI: 10.1016/j.neulet.2014.01.008

Genes

CBS
MTHFR
RFC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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