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Article

Inflammatory profile, age of onset, and the MTHFR polymorphism in patients with multiple sclerosis.

Journal of molecular neuroscience : MN - 1 May 2011

Alatab Sudabeh, Hossein-nezhad Arash, Mirzaei Khadijeh, Mokhtari Fatemeh, Shariati Gholamreza, Najmafshar Azam

Abstract excerpt

Both genetic and inflammatory factors are suspected in the etiology of multiple sclerosis (MS). Of genetic factors, the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been associated with increased levels of plasma homocysteine, a neuronal excitotoxic amino acid. Sclerotic patients also have elevated levels of plasma and CSF homocysteine. In this study, the association between C677T...

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Source

Identifiers

PMID: 21190091
DOI: 10.1007/s12031-010-9486-y

Genes

MTHFR
CRP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inflammatory profile, age of onset, and the MTHFR polymorphism in patients with multiple sclerosis.PMID 21190091Read ↗

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The Effects of The MTHFR 677C>T (Rs1801133) Genetic Variant on Susceptibility and Disability in Multiple Sclerosis Patients are Mediated by Homocysteine But Not Folate LevelsSemantic proximity Read ↗

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