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Article

Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA.

Nucleic acids research - 28 Oct 2024

Akita Masaki, Girvan Paul, Spirek Mario, Novacek Jiri, Rueda David, Prokop Zbynek, Krejci Lumir

Abstract excerpt

Homologous recombination (HR) factors are crucial for DSB repair and processing stalled replication forks. RAD51 paralogs, including RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, have emerged as essential tumour suppressors, forming two subcomplexes, BCDX2 and CX3. Mutations in these genes are associated with cancer susceptibility and Fanconi anaemia, yet their biochemical activities remain unclear. This study reveals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39268578
DOI: 10.1093/nar/gkae770
PMCID: PMC11514458

Genes

RAD51
BRCA2
RAD51B
RAD51C
RAD51D
XRCC2
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA.PMID 39268578Read ↗

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BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability.Semantic proximity Read ↗

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