Article

DMC1 and RAD51 bind FxxA and FxPP motifs of BRCA2 via two separate interfaces

2023-10-05

Abstract excerpt

In vertebrates, the BRCA2 protein is essential for meiotic and somatic homologous recombination (HR) due to its interaction with RAD51 and DMC1 strand exchange proteins (recombinases). The interaction is mediated by FxxA and FxPP motifs, whose defining feature is the invariant phenylalanine. The FxxA motifs, present in the eight BRC repeats in the central region of BRCA2, compete with the FxxA motif of the linker...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9016642b-c9f3-5bab-8d6d-06de8c0805a0
DOI: 10.1101/2023.10.05.561053

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DMC1 and RAD51 bind FxxA and FxPP motifs of BRCA2 via two separate interfacesDOI 10.1101/2023.10.05.561053Read

RAD51 Paralogs and RAD51 Paralog Complexes BCDX2 and CX3 Interact with BRCA2Semantic proximity Read

Structure and function of the RAD51B–RAD51C–RAD51D–XRCC2 tumour suppressorSemantic proximity Read

BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability.Semantic proximity Read

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.Semantic proximity Read

Breaking new ground into RAD51–BRC repeats interplay in Homologous RecombinationSemantic proximity Read

Moss BRCA2 lacking canonical DNA binding domain promotes efficient homologous recombination and binds to DNASemantic proximity Read

Dimerization Mediated by a Divergent Forkhead-associated Domain Is Essential for the DNA Damage and Spindle Functions of Fission Yeast Mdb1.Semantic proximity Read

Novel attributes of Hed1 affect dynamics and activity of the Rad51 presynaptic filament during meiotic recombination.Semantic proximity Read

Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2Semantic proximity Read

Functional Relationship of ATP Hydrolysis, Presynaptic Filament Stability, and Homologous DNA Pairing Activity of the Human Meiotic Recombinase DMC1.Semantic proximity Read

Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivitySemantic proximity Read

The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous RecombinationSemantic proximity Read